Multivariate analysis identified hypertension (odds ratio [OR] = 5.14, 95% CI: 1.15-22.87), baseline NIHSS score (OR = 1.25, 95% CI: 1.07-1.46), IGR (OR = 1.10, 95% CI: 1.01-1.21), HIR (OR = 380.71, 95% CI: 6.29-23,037.59), and cystatin C levels (OR = 26.65, 95% CI: 2.19-324.55) as independent predictors of poor outcome. Here, CST3 is linked to hypertensive disorder.