MGMT and neoplasm: Radial transition analysis was conducted to quantify feature changes across adjacent tumor regions.<h4>Results</h4>Spherical radiomics achieved AUCs of 0.82 for MGMT, 0.77 for EGFR, 0.76 for PTEN, and 0.79 for survival prediction, consistently outperforming conventional Euclidean radiomics (0.71, 0.61, 0.70, and 0.61, respectively).