<h4>Objective</h4>To investigate the expression pattern, diagnostic value, and molecular mechanism of CCAAT/enhancer-binding protein delta (<i>CEBPD</i>) in uterine leiomyoma (ULM)-associated fibrosis, and to identify novel diagnostic biomarkers and therapeutic targets for ULM.<h4>Methods</h4>We analyzed transcriptional profiles of two independent ULM cohorts (GSE64763, GSE95101) to screen differentially expressed genes and enriched pathways. The gene discussed is CEBPD; the disease is uterine corpus leiomyoma.