Thus, although spindle and kinetochore concentration of the SKA complex is mediated in part by the tubulin and tip-tracking capabilities provided by the SKA1 component of the SKA complex, transition from metaphase to anaphase requires the contribution of SKA3's C-terminal structural interface to mediate interaction between the SKA and NDC80 complexes.<h4>Significance statement</h4>Accurate chromosome segregation is essential for genomic stability, and its failure underlies developmental defects, and cancer. Here, SKA3 is linked to cancer.