KMO and schizophrenia: However, the direct functional consequences of these SNPs on KMO function have never been investigated.<h4>Methods</h4>Here we performed the first <i>in vitro</i> cell-based examination of the rs1053230 genotype on KMO expression, activity, cellular localisation and KMO-protein interactions, as well as examination of the effects of rs1053230 on schizophrenia-relevant clinical measures.