Mendelian randomization (MR) and summary-data-based MR (SMR) analyses were applied to prioritize candidate genes genetically associated with CRC risk.<h4>Results</h4>SPTBN2 was consistently upregulated in CRC tissues and was associated with poorer overall survival, remaining significant after adjustment for clinical covariates. The gene discussed is SPTBN2; the disease is colorectal carcinoma.