Finally, multivariate Cox regression analysis identified DSG2, EIF6, and EXO1 as independent prognostic factors for LUAD, highlighting their potential as biomarkers for prognosis and therapeutic targets in lung cancer.<h4>Conclusion</h4>In conclusion, DSG2, EIF6, and EXO1 were identified as key hypoxia-related genes in lung adenocarcinoma. The gene discussed is DSG2; the disease is lung cancer.