This study aimed to characterize the relationships between tumor-cell B7-H3 expression, immune-cell infiltration, clinicopathological features, and survival in malignant neuroblastic tumors, and to define an immune phenotype with potential translational relevance.<h4>Methods</h4>We retrospectively analyzed a population-representative cohort of 81 patients with neuroblastoma or nodular ganglioneuroblastoma diagnosed between 2009 and 2020. This evidence concerns the gene CD276 and neuroblastoma.