EGFR and epilepsy: Through deep phenotyping and reanalysis of exome sequencing data a rare, heterozygous, germline <i>EGFR</i> variant [NM_005228.5:c.866C > A p.(Ala289Asp)] was identified and shown to segregate with the neurological phenotype.<h4>Conclusion</h4>This case report expands the phenotypic spectrum associated with <i>EGFR</i> by demonstrating that a germline variant can underlie epilepsy and characteristic non-neoplastic MRI abnormalities.