Experimental studies demonstrated that EAT aggravated myocardial injury, fibrosis, and apoptosis, which were partially attenuated by IL-6 neutralization.<h4>Conclusion</h4>Integrating EAT radiomics with clinical parameters improves prediction of VR and MACE after AMI and is supported by experimental evidence linking EAT to post-infarction remodeling. Here, IL6 is linked to infarction.