FCGBP and metabolic dysfunction-associated steatotic liver disease: These findings indicate that FCGBP is associated with both hormonal dysregulation and hepatic lipid metabolic abnormalities under hyperandrogenic conditions.<h4>Conclusion</h4>This study identifies FCGBP as a potential molecular regulator in PCOS-NAFLD comorbidity and a candidate target for modulating both reproductive and metabolic dysfunctions.