A DHEA + high-fat diet-induced rat model was used to simulate key features of PCOS-NAFLD, and DHT+FFA-treated KGN and HepG2 cells were used for <i>in vitro</i> validation, with FCGBP silencing and rescue experiments performed to assess its functional role.<h4>Results</h4>FCGBP expression was significantly elevated in both ovarian and hepatic tissues in the rat model (P < 0.01). This evidence concerns the gene FCGBP and polycystic ovary syndrome.