Even after controlling for various clinical variables, the CHIP status still demonstrated an independent association with the primary composite endpoint (hazard ratio 2.02, 95% CI 1.11-3.67; <i>P</i> = .022).<h4>Conclusions</h4>CHIP was associated with the severity of coronary lesions and unfavorable clinical outcomes in patients with CKD. The gene discussed is STUB1; the disease is chronic kidney disease.