We aimed to develop and validate a multivariable model combining clinical and imaging parameters to predict clinically significant prostate cancer (csPCa).<h4>Methods</h4>This study included 1305 consecutive patients with suspected prostate cancer who underwent both mpMRI and 18F-PSMA PET/CT with biopsy at Peking University First Hospital. Here, FOLH1 is linked to Familial prostate cancer.