The performance of 34 algorithms in evaluating the pathogenicity of <i>GABRA1</i> variants was systematically analyzed, including accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Matthews correlation coefficient (MCC), F-score, and the area under the receiver operating characteristic curve (AUC).<h4>Result</h4>A total of 61 GABRA1 missense variants were analyzed, including 30 pathogenic/likely pathogenic variants from patients with <i>GABRA1</i>-associated epilepsies and 31 benign/likely benign controls from the gnomAD database. This evidence concerns the gene GABRA1 and epilepsy.