TERT and cholangiocarcinoma: In intrahepatic CCA tumours, higher <i>TERT</i> mRNA expression was positively correlated with gene expression patterns consistent with increased cell cycle activity and regulatory T cell signatures, and negatively associated with pathways of cell differentiation, adhesion and immune effector function.<h4>Conclusions</h4>These exploratory, hypothesis-generating findings suggest that the <i>TERT</i> rs10069690 variant may be associated with intrahepatic CCA risk and clinical outcomes, as well as with immune-related and proliferative pathways.