In OVX mice, MR improved bone microarchitecture and alleviated osteoporotic bone loss.<h4>Conclusion</h4>MR attenuates osteoporosis by suppressing osteoclast differentiation and function through regulating PI3K-AKT-GSK3β axis and ROS homeostasis, supporting its potential as a promisingtherapeutic candidate for osteoporosis. The gene discussed is GSK3B; the disease is osteoporosis.