DPF2 and colon adenocarcinoma: In addition, DPF2 was significantly associated with 11 COAD-related circulating metabolites, and mediation analyses suggested partial mediation through Ximenoylcarnitine (C26:1), 16α-hydroxy DHEA 3-sulfate, and Andro steroid monosulfate C19H28O6S (1).<h4>Conclusion</h4>DPF2 is a crotonylation reader associated with COAD risk and progression.