<h4>Introduction</h4>Visual dysfunction and retinal structural changes can occur early in Alzheimer's disease (AD), but the molecular basis of these early alterations remains unclear.<h4>Methods</h4>We performed quantitative proteomic profiling of the retina and brain from 4-week-old triple-transgenic AD (3xTg-AD) mice carrying human PS1M<sub>146V</sub>, APP<sub>Swe</sub>, and tau<sub>P301L</sub> mutations, prior to detectable retinal morphological abnormalities.<h4>Results</h4>Retinal morphology was normal in 4-week-old 3xTg-AD. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.