Our findings elucidate the role of TNFRSF1A<sup>+</sup> TAMs in driving DLBCL progression, highlight the TNFRSF1A/NF-κB/BAFF axis as a vulnerability in the DLBCL microenvironment, and propose curcumin as a viable therapeutic strategy to disrupt this supportive microenvironment. The gene discussed is TNFSF13B; the disease is diffuse large B-cell lymphoma.