This study aimed to investigate the crucial role and specific mechanism of the angiogenesis-related target THY1 in the development of acute colitis induced by dextran sulfate sodium (DSS) in mice.<h4>Methods</h4>Lentivirus-based systems were utilized to achieve both knockdown and overexpression of THY1 to explore the functional roles of THY1 in IBD development based on DSS-induced colitis mice model and co-culture system of intestinal epithelial cells and macrophages.<h4>Results</h4>THY1 significantly promotes DSS-induced colitis in the experimental mouse model. The gene discussed is THY1; the disease is inflammatory bowel disease.