<i>In vivo</i> validation further confirmed that ARID1B expression was significantly reduced in the atherosclerosis group, which was associated with prominent T cell and macrophage infiltration.<h4>Conclusion</h4>Cuproptosis-related gene ARID1B may reshape immune infiltration patterns in atherosclerosis, positioning it as a promising therapeutic target. This evidence concerns the gene ARID1B and atherosclerosis.