Top hubs (TP53: 758, EGFR: 512, AKT1: 415 connections) showed 60-67% cancer gene enrichment, with pathway clustering in p53 signalling (75%) and cell cycle regulation (67.7%).<h4>Conclusion</h4>Integrating protein interaction topology with imbalance-aware machine learning achieved 96% discrimination accuracy. This evidence concerns the gene TP53 and cancer.