TERF1 and chronic kidney disease: Moreover, silencing of tRF-1-ArgTCG-1-1, alone or together with β-catenin, attenuated TGF-β1-induced expression of RF-related markers <i>in vitro</i>.<h4>Conclusions</h4>Overall, these findings suggest that renal tubular epithelial cells tRF-1-ArgTCG-1-1 play a key role in RF and that the tRF-1-ArgTCG-1-1/β-catenin pathway is a potential therapeutic target for CKD and RF.