KRT19 and esophageal cancer: The results verified the potential of radiomics combined with machine learning technology in the preoperative prediction of CK19 expression.<h4>Conclusion</h4>This study developed a preoperative noninvasive prediction model based on radiomics and machine learning, which showed modest predictive performance in an exploratory setting in the evaluation of CK19 markers in patients with esophageal cancer, may provide preliminary support for further exploration in precision medicine.