Postoperative day 3 CRP was significantly lower after robotic surgery compared with laparoscopy [MD - 13.18 mg/l (95% CI - 22.29, - 4.08), p = 0.005), this was further demonstrated in colorectal cancer surgery subgroup analysis [MD -17.22 (95%CI -26.28, -8.17), p = 0.0002 I2= 0%]. This evidence concerns the gene CRP and colorectal cancer.