We investigated whether RNA modifications promote gastric cancer lymphatic metastasis by regulating EPHB4, a receptor tyrosine kinase implicated in lymphangiogenesis and nodal spread.<h4>Methods</h4>We integrated transcriptome sequencing of gastric cancer tissues, bioinformatic database analyses, and immunohistochemical validation to identify EPHB4 as a metastasis-associated gene. This evidence concerns the gene EPHB4 and gastric cancer.