<h4>Purpose</h4>To describe the phenotype of patients with age-related macular degeneration (AMD) carrying rare genetic variants in the complement factor H (<i>CFH</i>) and complement factor I (<i>CFI</i>) genes.<h4>Design</h4>Cross-sectional study.<h4>Participants</h4>Two hundred thirty-four patients with AMD carrying rare variants in <i>CFH</i> (n = 134) and <i>CFI</i> (n = 100) and 234 AMD noncarriers.<h4>Methods</h4>Genetic data of patients with AMD from the European Genetic Database were filtered for rare coding and splice-site variants in <i>CFH</i> and <i>CFI</i>. Here, CFI is linked to age-related macular degeneration.