<h4>Background</h4>This study aimed to investigate the clinical characteristics of anti-leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis and to identify significant risk factors associated with long-term functional prognosis.<h4>Methods</h4>We retrospectively analyzed the clinical data of 20 patients diagnosed with anti-LGI1 encephalitis at the Affiliated Hospital of Xuzhou Medical University from January 2021 to October 2024. This evidence concerns the gene LGI1 and encephalitis.