We delve into the specific shared risk loci, such as <i>TRIM32</i> and <i>SLC44A4</i>, and demonstrate how they converge on dysregulated biological pathways, notably IL-1, TNF-<i>α</i>, and MAPK/ERK signaling that drive both peripheral inflammation in endometriosis and neuroinflammation in migraine. Here, TRIM32 is linked to migraine disorder.