This study aimed to evaluate the biological and clinical relevance of ZNF473 in cancer through integrated bioinformatics analyses in combination with cell-based experimental validation.<h4>Methods</h4>ZNF473 function was investigated using comprehensive bioinformatics approaches in combination with <i>in vitro</i> and <i>in vivo</i> experimental models.<h4>Results</h4>ZNF473 exhibited differential expression across a range of normal tissues and malignancies and was significantly upregulated in more than 10 cancer types. The gene discussed is ZNF473; the disease is cancer.