This study aimed to identify clinical risk factors and evaluate the predictive value of serum hypocretin (Hcrt), neurofilament heavy chain (NfH), and interleukin-1 beta (IL-1β) for post-stroke sleep disorders.<h4>Methods</h4>We conducted a retrospective observational study of 256 patients with AIS. The gene discussed is IL1B; the disease is sleep disorder.