Mechanistically, hsa_circ_0093884 directly interacted with miR-375 and regulated SIX4 expression.<h4>Conclusion</h4>EPC-Exosomal hsa_circ_0093884 and baPWV are valuable diagnostic biomarkers associated with Alzheimer's disease. This evidence concerns the gene SIX4 and early-onset autosomal dominant Alzheimer disease.