This study evaluated the diagnostic value of arterial stiffness and endothelial progenitor CD34<sup>+</sup> progenitor-derived exosomal circRNAs (EPC-Exos circRNAs) in AD, and examined their associations with Comprehensive Geriatric Assessment (CGA) measures.<h4>Methods</h4>We measured brachial-ankle pulse wave velocity (baPWV) and conducted CGA in subjects with AD (n = 58), mild cognitive impairment (MCI, n = 31), and non-cognitive impairment (NCI, n = 36). Here, CD34 is linked to Alzheimer disease.