SIRT1 and Platelet storage pool disease: These complementary mechanisms converge on several key hallmarks of aging, including genomic instability, deregulated nutrient sensing, mitochondrial dysfunction, and chronic inflammation.<h4>Conclusion</h4>The anti-aging mechanisms of PQQ and SPD originate from distinct upstream biochemical processes but converge on shared signaling hubs, including the AMPK/SIRT1 axis and autophagy-related networks.