Mediation analysis indicated that gamma-glutamyl transpeptidase (GGT) and neutrophil count accounted for modest proportions of the associations with prediabetes progression (8.26 and 3.88%, respectively) and reversal (4.05 and 0.80%, respectively) through potential indirect pathways.<h4>Conclusion</h4>Cardiometabolic indices are associated with prediabetes progression to diabetes and reversal to normoglycemia, with TyG-WHtR showing relatively better discriminatory performance in this cohort. This evidence concerns the gene GGTLC1 and prediabetes syndrome.