No significant differences were observed for sirtuins, cytokines, lipid profile, glucose, and blood pressure.<h4>Conclusion</h4>Resveratrol increased serum Bcl-2 and cIAP2, and also reduced caspase 9 and circulating EPCs in postmenopausal women with chronic CHD, likely unrelated to circulating SIRT1 and SIRT3. The gene discussed is SIRT1; the disease is coronary artery disorder.