Development of web calculator based on Shiny app to facilitate clinical implementation.<h4>Results</h4>Four independent predictors of septic shock were identified through multivariate Firth logistic regression: fungal co-infection (adjusted odds ratio [aOR]: 9.01, 95% confidence interval [CI]: 2.26-36.49, <i>P</i> = .003), elevated admission glucose (aOR: 1.23, 95% CI: 1.04-1.48, <i>P</i> = .02), decreased antithrombin III (aOR: 0.96, 95% CI: 0.94-0.99, <i>P</i> = .004), and elevated interleukin-6 (aOR: 1.00, 95% CI: 1.00-1.01, <i>P</i> = .008). The gene discussed is IL6; the disease is coinfection.