This study examines the impact of oxytocin (<i>OXT</i>) polymorphisms (rs2740210, rs6133010, and rs2740209) in combination with alcohol dependence on anxiety and depression symptoms during acute alcohol withdrawal under different social and environmental contexts.<h4>Method</h4>A total of 414 Chinese Han male adults undergoing acute alcohol withdrawal were recruited. The gene discussed is OXT; the disease is major depressive disorder.