Sepsis markedly increased serum IL-6 (102.7 ± 13.6 pg/ml), TNF-α (98.5 ± 12.5 pg/ml), IL-1β (68.1 ± 8.9 pg/ml), and HMGB1 (3.5 ± 0.5 ng/ml), which were significantly reduced by Xiangdan injection at 5.0 ml/kg to 35.8 ± 5.2 pg/ml, 32.1 ± 5.3 pg/ml, 21.6 ± 3.8 pg/ml, and 1.1 ± 0.2 ng/ml, respectively (<i>P</i> < 0.01). Here, TNF is linked to Sepsis.