Their association with other AD-related phenotypes/disease progression remain largely unknown.<h4>Methods</h4>Associations between AQP4 variants, self-reported sleep measures, and AD-related phenotypes in cognitively unimpaired individuals with evidence of Aβ accumulation were examined using data from the Australian Imaging, Biomarkers and Lifestyle study.<h4>Results</h4>AQP4 variants were directly associated with regional brain volumes, atrophy, and cognition. This evidence concerns the gene AQP4 and Alzheimer disease.