Neither CD4+ nor Foxp3+ cells in pCRC were individually predictive of survival, but a higher Foxp3+/CD4+ cells ratio in OM of pCRC in the metachronous group was associated with shorter DFS (hazard ratio (HR): 2.34, 95% confidence interval (CI): 1.14-4.79, p = 0.02) and TTR. This evidence concerns the gene CD4 and ocular melanoma.