The expression of extracellular matrix components, Takeda G protein-coupled receptor 5 (TGR5), glucagon-like peptide-1 receptor (GLP-1R), and nuclear factor kappa B (NF-κB) p65 was examined by in adenine-induced CKD rats.<h4>Results</h4>UCG improved renal function and alleviated kidney fibrosis in adenine-induced CKD rats. The gene discussed is GPBAR1; the disease is chronic kidney disease.