TP53 and myelodysplastic syndrome: However, comprehensive studies that characterize the full mutation landscape and clinical correlations in Asian populations are still limited.<h4>Aims</h4>This research aims to elucidate the mutation spectrum and baseline characteristics of TP53-mutated MDS in a Chinese cohort, thereby enhancing clinical understanding and treatment approaches.<h4>Methods and results</h4>A total of 161 TP53-mutated patients from 1589 newly diagnosed MDS with next-generation sequencing (NGS) data via a targeted 96-gene sequencing panel were analyzed to assess genomic alterations.