Given that Vascular Endothelial Growth Factor A (VEGFA) serves as the dominant driver of angiogenesis, we hypothesized that METTL14 may govern VEGFA expression to modulate the vascular niche in hepatocellular carcinoma (HCC).<h4>Aims</h4>This study aimed to elucidate the regulatory axis between METTL14 and VEGFA in HCC. This evidence concerns the gene METTL14 and hepatocellular carcinoma.