PTEN and Cognitive impairment: This study aimed to investigate whether PTEN nuclear translocation mediates sevoflurane-induced hippocampal synaptic and cognitive deficits in aged female mice, and whether activation of ERα can mitigate these effects.<h4>Methods</h4>Aged female mice were exposed to repeated sevoflurane, followed by assessment of PTEN subcellular localization using Western blot and immunofluorescence.