By integrating analyses of human UC tissues, DSS-induced acute and chronic colitis mouse models, and mechanistic <i>in vitro</i> experiments, we demonstrate that METTL1 enhances N7-methylguanosine (m7G) modification of SLC7A11 mRNA, thereby stabilizing the transcript and sustaining SLC7A11 expression in inflammatory settings. Here, SLC7A11 is linked to Chronic colitis.