PRKN and pulmonary emphysema: Therefore, this study aimed to investigate the role of PRKN Ser131 phosphorylation in CS-induced impairment of mitophagy and epithelial cell senescence, and to explore the underlying mechanism.<h4>Methods</h4>This laboratory-based experimental study utilized human bronchial epithelial BEAS-2B cells exposed to cigarette smoke extract (CSE) and a mouse model of CS-induced emphysema.