GSDMD and periodontitis: These key biomarkers correlated positively with Tb.Sp and CEJ-ABC, and they colocalized with gasdermin D (GSDMD) in areas of severe damage, which suggests a role in pyroptosis-related bone destruction.<h4>Discussion</h4>Inflammatory signals in saliva and serum can reflect active destruction of alveolar bone micro-structure in periodontitis.