Large animal models, particularly pigs, are increasingly recognized as promising preclinical systems for translating fundamental immunological and oncological discoveries into clinically relevant applications.<h4>Methods</h4>Given the pivotal role of the carcinoembryonic antigen (CEA) family, both as key regulators of immune responses (e.g., CEACAM1) and as tumor antigens (e.g., CEA) in humans, we performed a comprehensive characterization of the porcine CEA gene family. Here, CEACAM5 is linked to neoplasm.