In metastatic patients, PTPRR-high tumor cells were associated with an immunosuppressive microenvironment by interacting with T cells and other immune cells through TGFβ, CCL, and CXCL pathways.<h4>Conclusion</h4>PTPRR serves as an epithelial-specific biomarker closely associated with PDAC progression. This evidence concerns the gene TGFB1 and neoplasm.