CRP and Neonatal sepsis: SROC curve analysis further demonstrated robust predictive value for both biomarkers, with the AUC of IL-27 (0.92) being notably higher than that of CRP (0.84).<h4>Conclusions</h4>The findings of this updated systematic review and meta-analysis indicate that IL-27 has superior diagnostic accuracy to CRP for the identification of neonatal sepsis.